Guix System is very usable as a main OS if your hardware is compatible. Linux-libre gives some people trouble with their GPU or WiFi. I use a ThinkPad T440p wit

Guix System is very usable as a main OS if your hardware is compatible. Linux-libre gives some people trouble with their GPU or WiFi. I use a ThinkPad T440p with the WLAN card removed, and everything that remains works fine. If you need blobs for an AMD GPU or WLAN, you likely need to swap out linux-libre for linux in your config. I haven't done this myself, but I know a few people who have done so. Also consider that discussion of non-free bits like this are not allowed in the official IRC and mailing lists, so you'll have to either be on your own or find the semi-secret places where guix users use non-free things. All that aside, I've spent time with NixOS and Guix System both, and much prefer the latter. Nix has more packages, but some of them (which I actually use in everyday life) are broken in odd ways where they work fine in Guix. I also like to use a distro without systemd when possible, and find the guix community feels more alive/active. Getting more Guix users (and packagers) will help narrow the gap as well. There are enough packages that I don't miss too much in daily use, and you can comfortably get all your emacs packages through guix, I just often can't try some new program when I first learn about it.