Don't know about Guix System but I've used NixOS as main OS for third year now just fine. Of course for coding you'll need to learn how to create (basically lea

Don't know about Guix System but I've used NixOS as main OS for third year now just fine. Of course for coding you'll need to learn how to create (basically learn Nix, the language) an environment that has the libraries used in the specific project. The last question applies to any distro. Gaming is viable if you've GPU passthrough.