How would you know the difference between the first chart and the third chart a-priori. Say you saw the third chart and mistook it for the first chart? Having

How would you know the difference between the first chart and the third chart a-priori. Say you saw the third chart and mistook it for the first chart? Having looked at 10's of profiles using frameworks and seeing the exact same profiles across the applications, can we ignore the framework part of it? Recently we spent a week profiling an application trying to find a very bad, but very hard to reproduce bug. After a week of profiling, debugging, pouring over logs, etc. It turns out the problem might have been a defective controller on the storage appliance the database was using. How can you know a-priori what you are looking at?