3 ms·
It's well known that alcoholics are for the most part better metabolizers of alcohol (see https://www.sciencedirect.com/science/article/pii/S166526811932143X#se
by oaktrout 5y ago
It's well known that alcoholics are for the most part better metabolizers of alcohol (see https://www.sciencedirect.com/science/article/pii/S166526811932143X#sec0090 https://www.sciencedirect.com/science/article/pii/S166526811... Current concepts in alcohol metabolism, Caballeria), but its not at all related to liver enlargement. My understanding is that an enlarged liver is a symptom of alcoholic liver disease, not a physiologic adaptation to better metabolize alcohol. The current consensus is that most of the increased metabolism of alcohol comes from enzyme upregulation in the liver.
The authors misunderstanding of physiology makes me doubt any further conclusions he makes.
- giantg2 5y ago"Moreover, in human studies it has been found that alcohol consumption produces an increase in the ethanol elimination rate, specially at high concentrations, which is when the action of MEOS take place.37 This is important since it leads to a greater plasma concentration of acetaldehyde as well as an increase in toxic metabolites which may cause liver damage." Ah, this is the thing I was mentioning earlier, but my other source didn't say that it increased the elimination rate.