3 ms·
> since they have to be (relatively) stable as a monomer before locking in place What is your basis for this claim?
by cowsandmilk 5y ago
> since they have to be (relatively) stable as a monomer before locking in place
What is your basis for this claim?
- l33tman 5y agoIf the monomer is completely unstable by itself, and wouldn't fold, I'm pretty sure 5 of them are not going to fold simultaneously into a multimer. So it would be a good guess that the monomers are going to fold first into something that at least looks roughly like the final product and then assemble and change configuration. But no I haven't read any articles studying this in detail. I do recall seeing studies on the evolution of oligomers, where the monomer exists by itself but evolves to polymerize at the expense of its monomeric stability.