This has got to be HN's favorite intermittent fasting meme. It combines a "well actually" with a false sense of mathematical precision - both are crack for HN.

This has got to be HN's favorite intermittent fasting meme. It combines a "well actually" with a false sense of mathematical precision - both are crack for HN. But it's more false than true. The truth in it is that mice lose a greater percent of their body mass in the first 24 hours. Also mice will die if deprived for food for ~5 days. So at 24 hours, they're much closer to death than a human. But that's not really what we care about with IF. Most people care about the metabolic transitions prompted by fasting,[0] which are strikingly homologous across mammals. The variance that does exist is pretty well captured by the models that underlie those metabolic stages. This article is about something going on in the brain, which is harder to assess in humans for obvious reasons. But one of the big benefits of fasting that kicks in around the 24 hour mark is macro-autophagy. We know macro-autophagy is occuring in the brains of mice by 24 hours [1] and we know that macro-autophagy has a similar time course in humans and mice in the tissues we're able to sample.[2] [0] https://usetemper.com/learn/metabolic-step-by-step/ https://usetemper.com/learn/metabolic-step-by-step/ [1] https://pubmed.ncbi.nlm.nih.gov/20534972/ https://pubmed.ncbi.nlm.nih.gov/20534972/ [2] https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1271513 https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1...