I use an Evoluent Vertical Mouse, which is about $85. I will never go back to normal wrist-twist mice. It's also good to have a thin and large mouse pad, like

I use an Evoluent Vertical Mouse, which is about $85. I will never go back to normal wrist-twist mice. It's also good to have a thin and large mouse pad, like the SteelSeries QcK.