3 ms·
You are absolutely right that it’s dumb that it took so long for us to have discovered these receptors so late. Consider for a second though that this might be
by ramraj07 5y ago
You are absolutely right that it’s dumb that it took so long for us to have discovered these receptors so late. Consider for a second though that this might be a symptom of a fundamental myopia in the way biological science itself has progressed? That perhaps we have been congratulating people for the wrong thing - discovering expected genes instead of finding new ways to do everything faster or finding things that are completely unexpected. As much as heat and pressure sound like fundamental senses (they are), they aren’t very high on the priority list of basically anyone trying to do biology with applications in mind. Heat receptors don’t cure cancer or cystic fibrosis. Or Covid.
- Duller-Finite 5y agoTRP channels were first cloned over 20 years ago, and are indeed medically relevant for nociception and pain. The piezos are equally relevant; knockouts are embryonically lethal, and the function of mechanosenstation in somatosenation and in general continue to be elucidated. For instance, it was only a few years that they were identified as being required for the baroreceptor reflex.
- u2c4m6 5y agoIt is truly astounding how little you know about biology and then talk so confidently about these Nobel prizes. You realize that cancer and Covid research builds on this type of stuff, right? Well you probably don't since you have demonstrated throughout this thread that you have the biological knowledge of a potato.