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To clarify, the modified HIV virus in this case was used as a vector to deliver an antibody specific to the cancer onto a T-cell. The T-cell then goes on to des
by hvs 15y ago
To clarify, the modified HIV virus in this case was used as a vector to deliver an antibody specific to the cancer onto a T-cell. The T-cell then goes on to destroy the cancer. HIV is one of the most efficient vectors for genes.
http://en.wikipedia.org/wiki/Viral_vector http://en.wikipedia.org/wiki/Viral_vector
http://en.wikipedia.org/wiki/Lentivirus http://en.wikipedia.org/wiki/Lentivirus
http://en.wikipedia.org/wiki/Chimeric_antigen_receptor http://en.wikipedia.org/wiki/Chimeric_antigen_receptor
http://www.nejm.org/doi/full/10.1056/NEJMoa1103849 http://www.nejm.org/doi/full/10.1056/NEJMoa1103849
EDIT: Also note that the HIV vector is used to modify the T-cell before it is inserted into the human. The HIV is never actually inserted into the human (in this case).
- amitutk 15y agoSuch viral vectors are routinely used in the lab to knock in a variety of genes in the cell. Vector is really the packaging. What was important in the study was the actual antigen which has packaged in the vector.
- hvs 15y agoWithout a doubt. I was only commenting on the HIV vector because there are so many that say, "What the hell?" when they hear "HIV."
- zacharycohn 15y agoI know I did, until I read further into the article.