"Calorie restriction for obesity treatment results in weight loss—initially—giving patients the impression they have conscious control over their body weight. B

"Calorie restriction for obesity treatment results in weight loss—initially—giving patients the impression they have conscious control over their body weight. But predictable biological responses oppose weight loss, including decreased metabolic rate and elevated hunger. Therefore, ongoing weight loss requires progressively more severe calorie restriction, even as hunger increases. Few people achieve clinically significant weight loss over the long term with this approach. Those who cannot might feel implicitly stigmatized as lacking in self-control." Waiting for the classic Calories In Calories Out comment found in every HN post about obesity, that completely misses the mark every single time. The human body isn't a tube and a simple machine that works on pure energy, but a complex chemical machine with feedback loops and multiple pathways, some more efficient, beneficial or just preferable than others, depending on genes, environment, food composition or health of the person in general. What if, instead of starving yourself eating only salads and plain white rice because CICO, there's a better and more efficient pathway that doesn't affect the "I'm hungry" feedback loop as much? Every time I hear "CICO" I cringe as it's an ignorant shutdown of the whole discussion and forgets we still have not completely figured out how the whole energy intake and expenditure system in the human body works.