3 ms·
Full text here it's not trivial to find [1]. This study doesn't show that molnupiravir (rNHC) is genotoxic at levels effective for treating covid. Dosage of 1µ
by sterlind 5y ago
Full text here it's not trivial to find [1].
This study doesn't show that molnupiravir (rNHC) is genotoxic at levels effective for treating covid. Dosage of 1µm reduced COVID+ cells by 15x, while 3µm removed the infection entirely. [2] 1µm and even 3µm dosing didn't lead to any statistically significant genotoxicity, only 10µm showed effects [3].
The authors know this, because their conclusion is that the risk of genotoxicity "might not be zero." They have not demonstrated that therapeutic doses cause any statistically significant increase in mutations.
1. https://academic.oup.com/jid/article/224/3/415/6272009?login=true https://academic.oup.com/jid/article/224/3/415/6272009?login...
2. https://academic.oup.com/view-large/figure/283696469/jiab247f0001.jpg https://academic.oup.com/view-large/figure/283696469/jiab247...
3. https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/224/3/10.1093_infdis_jiab247/1/jiab247_suppl_supplementary_figure_s4.jpeg?Expires=1636120100&Signature=46F7l7qKHHhve-m6e~E39-3Fqhs9Jd8rXk-Y4pKsa8raT-uKxnOGRJlQ4AD-TUpM2TtSBL2ygq-EpTpaxPWnxEk69Bw4LgT4ZnlJE1SetT2vC2lEIjp1horcdstiBAqw8T9cAfvU8v0c~4l89gHURdVl0eKAqJlWoqH547GXNPwDHEsSvcMe4yUR060e9QT6vcYz7gintGnI0hDGpRrSYyXFiUg2-xMfSCxlv~F3b10yJBWX1UrsPt6ZC-BJ2EMaPLpdPfWrhQzy4TQSw9TSJxq6niS2h7eexV4qX3vUIFg6AyN5zBb-sDGmT9NwZb-e6bxzPfcuCC-xUa9BHrya2w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA https://oup.silverchair-cdn.com/oup/backfile/Content_public/...