3 ms·
The problem is that if the in-vitro studies are correct on their dose curves, then the majority of the human trials are at ineffective doses. This doesn't mean
by kortex 5y ago
The problem is that if the in-vitro studies are correct on their dose curves, then the majority of the human trials are at ineffective doses. This doesn't mean they must be wrong, but it's not a good look. If the studies were showing unequivocal benefit, we could overlook the dose curves. But the studies are still quite equivocal.
On the other hand, molnupirivir is a nucleoside polymerase inhibitor, with a slam-dunk mechanism of action, evidence of efficacy against a broad range of viruses, and increasingly compelling human safety profile.
I don't know if Merck is stalling but the ivermectin case is certainly less compelling.
https://www.science.org/content/blog-post/ivermectin-covid-19-therapy https://www.science.org/content/blog-post/ivermectin-covid-1...
- ashtonkem 5y agoThose in vitro studies were done with Vero cells, from the kidneys of a green monkey, which do not appear to be a good analogue for human lung cells with Covid. Even if you could give the Ivermectin doses recommended by the study without killing the patient, chances are it wouldn’t actually work.