3 ms·

Seems like a lot of added potential risk for anyone at low odds of being hospitalized for Covid. https://pesquisa.bvsalud.org/global-literature-on-novel-corona

Seems like a lot of added potential risk for anyone at low odds of being hospitalized for Covid. https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1250916 https://pesquisa.bvsalud.org/global-literature-on-novel-coro...

roflc0ptic 5y ago
Curious why this is downvoted. Is this person wrong? It seems like an important detail if the drug is actually mutagenic in mammalian cells.
- sterlind 5y ago
  It is misleading but not directly wrong. Excessively high doses lead to mutations, but that's true for aspartame too. Nothing suggests that a therapeutic dose for a short time will give you cancer any more than X-rays from plane travel (i.e. there's a causal mechanism, but it's not statistically significant.) See my reply to them for more details.
  - cinntaile 5y ago
    Judging from his comment history he seems to spread a lot of this kind of covid "doubting" information.
cinntaile 5y ago
It clearly states that clinical use should be carefully considered, so don't worry they're aware of its side-effects.
sterlind 5y ago
Full text here it's not trivial to find [1]. This study doesn't show that molnupiravir (rNHC) is genotoxic at levels effective for treating covid. Dosage of 1µm reduced COVID+ cells by 15x, while 3µm removed the infection entirely. [2] 1µm and even 3µm dosing didn't lead to any statistically significant genotoxicity, only 10µm showed effects [3]. The authors know this, because their conclusion is that the risk of genotoxicity "might not be zero." They have not demonstrated that therapeutic doses cause any statistically significant increase in mutations. 1. https://academic.oup.com/jid/article/224/3/415/6272009?login=true https://academic.oup.com/jid/article/224/3/415/6272009?login... 2. https://academic.oup.com/view-large/figure/283696469/jiab247f0001.jpg https://academic.oup.com/view-large/figure/283696469/jiab247... 3. https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/224/3/10.1093_infdis_jiab247/1/jiab247_suppl_supplementary_figure_s4.jpeg?Expires=1636120100&Signature=46F7l7qKHHhve-m6e~E39-3Fqhs9Jd8rXk-Y4pKsa8raT-uKxnOGRJlQ4AD-TUpM2TtSBL2ygq-EpTpaxPWnxEk69Bw4LgT4ZnlJE1SetT2vC2lEIjp1horcdstiBAqw8T9cAfvU8v0c~4l89gHURdVl0eKAqJlWoqH547GXNPwDHEsSvcMe4yUR060e9QT6vcYz7gintGnI0hDGpRrSYyXFiUg2-xMfSCxlv~F3b10yJBWX1UrsPt6ZC-BJ2EMaPLpdPfWrhQzy4TQSw9TSJxq6niS2h7eexV4qX3vUIFg6AyN5zBb-sDGmT9NwZb-e6bxzPfcuCC-xUa9BHrya2w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA https://oup.silverchair-cdn.com/oup/backfile/Content_public/...

roflc0ptic 5y ago

Curious why this is downvoted. Is this person wrong? It seems like an important detail if the drug is actually mutagenic in mammalian cells.

sterlind 5y ago
It is misleading but not directly wrong. Excessively high doses lead to mutations, but that's true for aspartame too. Nothing suggests that a therapeutic dose for a short time will give you cancer any more than X-rays from plane travel (i.e. there's a causal mechanism, but it's not statistically significant.) See my reply to them for more details.
- cinntaile 5y ago
  Judging from his comment history he seems to spread a lot of this kind of covid "doubting" information.

cinntaile 5y ago

It clearly states that clinical use should be carefully considered, so don't worry they're aware of its side-effects.

sterlind 5y ago

Full text here it's not trivial to find [1]. This study doesn't show that molnupiravir (rNHC) is genotoxic at levels effective for treating covid. Dosage of 1µm reduced COVID+ cells by 15x, while 3µm removed the infection entirely. [2] 1µm and even 3µm dosing didn't lead to any statistically significant genotoxicity, only 10µm showed effects [3]. The authors know this, because their conclusion is that the risk of genotoxicity "might not be zero." They have not demonstrated that therapeutic doses cause any statistically significant increase in mutations. 1. https://academic.oup.com/jid/article/224/3/415/6272009?login=true https://academic.oup.com/jid/article/224/3/415/6272009?login... 2. https://academic.oup.com/view-large/figure/283696469/jiab247f0001.jpg https://academic.oup.com/view-large/figure/283696469/jiab247... 3. https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/224/3/10.1093_infdis_jiab247/1/jiab247_suppl_supplementary_figure_s4.jpeg?Expires=1636120100&Signature=46F7l7qKHHhve-m6e~E39-3Fqhs9Jd8rXk-Y4pKsa8raT-uKxnOGRJlQ4AD-TUpM2TtSBL2ygq-EpTpaxPWnxEk69Bw4LgT4ZnlJE1SetT2vC2lEIjp1horcdstiBAqw8T9cAfvU8v0c~4l89gHURdVl0eKAqJlWoqH547GXNPwDHEsSvcMe4yUR060e9QT6vcYz7gintGnI0hDGpRrSYyXFiUg2-xMfSCxlv~F3b10yJBWX1UrsPt6ZC-BJ2EMaPLpdPfWrhQzy4TQSw9TSJxq6niS2h7eexV4qX3vUIFg6AyN5zBb-sDGmT9NwZb-e6bxzPfcuCC-xUa9BHrya2w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA https://oup.silverchair-cdn.com/oup/backfile/Content_public/...