5 ms·

I think it's disappointing that this thread has devolved into a political discussion that is hardly related to the topic. The scientific/medical achievement her

I think it's disappointing that this thread has devolved into a political discussion that is hardly related to the topic. The scientific/medical achievement here seems significant. As an MD, the difference between calling in a script for a pill and arranging for outpatient infusion therapies is vast.

sudosysgen 5y ago
Indeed. The opportunity for prophylaxis with an oral antiviral is also amazing.
- deleted 5y ago
  [deleted]
- Marsymars 5y ago
  I definitely would not want to be taking a mutagenic prophylactically.
  - sudosysgen 5y ago
    I was talking about post exposure prophylaxis. This drug does have mutation concerns. If I'm choosing between a taking the drug right now for 2-3 days in lower doses Vs a 50% chance of taking much higher doses for 2 weeks, id take the former.
    - freemint 5y ago
      The moment you have symptoms peak replication is already over for two da,s. It's to late by then.
      - sudosysgen 5y ago
        That's not how PEP works. You'd be taking it after having had a contact, before symptoms.
dougmwne 5y ago
Thank you for weighing in. I am hugely excited about this and immediately sent a message to all my family. I know people who died because they didn't know that antibody treatments were available and effective when given early enough. I very likely saved my own father's life by helping him to get an antibody treatment when he and his own doctor knew nothing about it at the time. When we're talking about pre-hospitalization, this knowledge is everything. This pill is hugely promising and I will be following it closely.
- helloguillecl 5y ago
  Would you mind to share which antibody treatment were you able to get for your father? I would be useful for the rest of us if we ever find ourselves in this situation again.
  - dougmwne 5y ago
    It was the Monoclonal antibody treatment that is part of the official NIH treatment recommendations. There are a few formulations with different brand names, but the recommendation is to take whatever is first available and there is not published evidence of one being better than the others. I don't even know which he was given and does not matter at this point. The infusion lasted several hours at our local hospital and required a positive Covid test and needed to be ordered by a doctor stating that there were enough comorbidities to justify the treatment, the went through a lottery weighed on risk factors, then an appointment was scheduled. It is free to the patient but very expensive to taxpayers. It needs to be given as soon as possible after symptom onset to have the greatest effect. The odd thing is that you have to start pushing strongly on the paperwork to get this fairly invasive treatment when you still feel perfectly well in order to get it in time. You have to act quickly purely on your risk factors and not on how you are feeling. That's why this pill has so much potential. It could be handed out immediately after a positive test and prescription and is easy enough that it becomes "why not" instead of "why". Of course this is a very new drug, but for certain high risk people it may make a ton of sense.
  - EricE 5y ago
    There are actually a multitude of treatments beyond waiting for thing to get bad enough that you need to go to the hospital: https://aapsonline.org/covidpatientguide/ https://aapsonline.org/covidpatientguide/ This is also worth a watch: https://www.youtube.com/watch?v=QAHi3lX3oGM https://www.youtube.com/watch?v=QAHi3lX3oGM
deleted 5y ago
[deleted]
- deleted 5y ago
  [deleted]
SideburnsOfDoom 5y ago
> devolved into a political discussion Welcome to the "intelligentsia" debating anti-Covid measures. On the topic, you usually see worse than this.
andybak 5y ago
Be wary of commenting on the tone of a thread. Skimming it 39 minutes later and it seems a very reasonable, varied thread. Wait for voting to do it's thing.
stevespang 5y ago
Personally, it's disappointing the hideous fees MD's and hospitals charge - - not to mention the fact the Molnupiravir costs $255 PER PILL, and most all the research funding was with taxpayer money to begin with.

sudosysgen 5y ago

Indeed. The opportunity for prophylaxis with an oral antiviral is also amazing.

deleted 5y ago
[deleted]
Marsymars 5y ago
I definitely would not want to be taking a mutagenic prophylactically.
- sudosysgen 5y ago
  I was talking about post exposure prophylaxis. This drug does have mutation concerns. If I'm choosing between a taking the drug right now for 2-3 days in lower doses Vs a 50% chance of taking much higher doses for 2 weeks, id take the former.
  - freemint 5y ago
    The moment you have symptoms peak replication is already over for two da,s. It's to late by then.
    - sudosysgen 5y ago
      That's not how PEP works. You'd be taking it after having had a contact, before symptoms.

dougmwne 5y ago

Thank you for weighing in. I am hugely excited about this and immediately sent a message to all my family. I know people who died because they didn't know that antibody treatments were available and effective when given early enough. I very likely saved my own father's life by helping him to get an antibody treatment when he and his own doctor knew nothing about it at the time. When we're talking about pre-hospitalization, this knowledge is everything. This pill is hugely promising and I will be following it closely.

helloguillecl 5y ago
Would you mind to share which antibody treatment were you able to get for your father? I would be useful for the rest of us if we ever find ourselves in this situation again.
- dougmwne 5y ago
  It was the Monoclonal antibody treatment that is part of the official NIH treatment recommendations. There are a few formulations with different brand names, but the recommendation is to take whatever is first available and there is not published evidence of one being better than the others. I don't even know which he was given and does not matter at this point. The infusion lasted several hours at our local hospital and required a positive Covid test and needed to be ordered by a doctor stating that there were enough comorbidities to justify the treatment, the went through a lottery weighed on risk factors, then an appointment was scheduled. It is free to the patient but very expensive to taxpayers. It needs to be given as soon as possible after symptom onset to have the greatest effect. The odd thing is that you have to start pushing strongly on the paperwork to get this fairly invasive treatment when you still feel perfectly well in order to get it in time. You have to act quickly purely on your risk factors and not on how you are feeling. That's why this pill has so much potential. It could be handed out immediately after a positive test and prescription and is easy enough that it becomes "why not" instead of "why". Of course this is a very new drug, but for certain high risk people it may make a ton of sense.
- EricE 5y ago
  There are actually a multitude of treatments beyond waiting for thing to get bad enough that you need to go to the hospital: https://aapsonline.org/covidpatientguide/ https://aapsonline.org/covidpatientguide/ This is also worth a watch: https://www.youtube.com/watch?v=QAHi3lX3oGM https://www.youtube.com/watch?v=QAHi3lX3oGM

deleted 5y ago

[deleted]

deleted 5y ago
[deleted]

SideburnsOfDoom 5y ago

> devolved into a political discussion Welcome to the "intelligentsia" debating anti-Covid measures. On the topic, you usually see worse than this.

andybak 5y ago

Be wary of commenting on the tone of a thread. Skimming it 39 minutes later and it seems a very reasonable, varied thread. Wait for voting to do it's thing.

stevespang 5y ago

Personally, it's disappointing the hideous fees MD's and hospitals charge - - not to mention the fact the Molnupiravir costs $255 PER PILL, and most all the research funding was with taxpayer money to begin with.