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> I have a degree in CS and minored in BioEngineering. > We also don’t know how long the mRNA lasts, so it can keep generating the cytotoxic spike proteins for
by Mordisquitos 5y ago
> I have a degree in CS and minored in BioEngineering.
> We also don’t know how long the mRNA lasts, so it can keep generating the cytotoxic spike proteins for an unknown length of time.
I have a degree in Biology, a Master's in Bioinformatics, and I worked for 4 years in a wetlab working with actual RNA. We know very well how long mRNA lasts: it lasts very, very, very little. In fact, one of the challenges of mRNA vaccines was precisely to make their RNA be stable enough for storage and make it survive long enough to enter our cells to be translated.
Not only is RNA a structurally unstable molecule thanks to the oxygen in position 2 of the ribose (as opposed to the deoxyribose in DNA), but in its unbound form it is actively degraded by a variety of RNAse enzymes, for two reasons: first, mRNA functions as a short-term messenger and it would get in the way of the cell's ability to quickly regulate its own gene expression; second, the body does not trust any old RNA floating about as it may well be viral in origin. In fact, we even release very stable RNAses through our skin, which are the bane of labwork when working with RNA.