I suggest you start out with some basic chemistry. There you can find the data on how the amino acid chains line up and fold and twist. There was that game some

I suggest you start out with some basic chemistry. There you can find the data on how the amino acid chains line up and fold and twist. There was that game somebody released where you "fold" with the mouse. I think it was an experiment to find out if humans can do the folding faster then computers. That should give you an idea of the problem. The core problem in protein folding is that all the parts heavily interact with each other. And that means that it is not easily split across nodes. Forget about networked nodes, the latency is way too big. Some academic groups have proposed a funnel shape to the folding probabilities. That is to say that initially things could go in any direction and the possibility space is HUGE. But as the protein grows the number of possible moves collapse quickly and you are left with very few moves at the end. I think the Features in Biotech podcast had at least one show on protein folding, fun to listen to. Hope this helps, enjoy yourself.