4 ms·

My takeaway was googling "Irisin pills"~

• captainbland 5y ago
  "Next, the researchers delivered irisin directly into the mice’s brains." That sentence is not giving me much hope that they expect the hormone to survive digestion.
  • serrel 5y ago
    Once it's in the bloodstream, the hormone passes the blood brain barrier. "In addition, the researchers found that irisin could cross the blood-brain barrier to act on the brain."
  • heavyset_go 5y ago
    I'm not advocating for it, but there are ways to bypass first-pass metabolism or to get certain compounds or proteins through the blood-brain barrier.