3 ms·
I'd like to see a study on those with naturally low cholesterol. My dad and I (and some of his ancestors) have very low cholesterol and great LDL and HDL number
by RegBarclay 5y ago
I'd like to see a study on those with naturally low cholesterol. My dad and I (and some of his ancestors) have very low cholesterol and great LDL and HDL numbers without any medication or special diet. Dad's been told he has really good genes. Except he has AD. His sister has just started showing signs of dementia. Their mother died with AD. I'm not liking my odds here.
Could be that the usual AD genes are strong. Could be that those genes co-occur commonly with the same genes that allow me to be a butter and bacon eating machine. Could be that low cholesterol is a really bad thing for brain health. I figure I've got about 10 or 20 years to find out.
- JamesBarney 5y agoNigerians have lots of APOE4 (a gene that leads to much higher rates of alzheimers), and really low cholesterol. And they also have lower rates of AD. I think base on current evidence your family might just have great cholesterol genes and bad AD genes. Btw how old was your father, aunt and grandmother when they got AD?
- RegBarclay 5y agoDad's 85. He was 82 when it became clear he was having significant problems, but mom had been saying he was having lesser problems before that. My aunt has just turned 80. Grandma died at 87. I'm not sure exactly when she became symptomatic, but it was also around 80. I'm 53. I figure I have 20-25 good years left. The cholesterol connection is of interest because of my family history, but my current thinking is that the so-called Type 3 Diabetes pathway seems very plausible. Whether it affects brain health or not, I'm on the "carbs are bad" bandwagon.
- supperburg 5y agoGoogle Mary Newport