5 ms·
From OP: > [A]fter decades of research and billions of patient-years of use data, it doesn’t appear that people taking statins are at greater risk of these con
by occamrazor 5y ago
From OP:
> [A]fter decades of research and billions of patient-years of use data, it doesn’t appear that people taking statins are at greater risk of these conditions [cognitive impairment, dementia, hemorrhagic stroke]. In fact, population studies actually suggest that statin use is associated with a reduced incidence of dementia, but observational studies like these are incapable of determining a cause-and-effect relationship.
In other words: no, it doesn’t. The article is however a good overview of cholesterol metabolism in the brain and effects of statins.
- gchokov 5y agoBetteridge's law[1] of headlines is an adage that states: "Any headline that ends in a question mark can be answered by the word no." It is named after Ian Betteridge, a British technology journalist who wrote about it in 2009, although the principle is much older.[1][2] The adage fails to make sense with questions that are more open-ended than strict yes–no questions. [1] https://en.wikipedia.org/wiki/Betteridge%27s_law_of_headlines https://en.wikipedia.org/wiki/Betteridge%27s_law_of_headline...
- vlovich123 5y agoIs Betteridge’s law ever useful?
- chiefsucker 5y agoIsn’t this already one recursion level too deep? ;)
- canadaduane 5y agoNice try, but we need to see your article to know it's a legit headline :)
- tsoukase 5y agoAre you starting a proof of Gödel's incompleteness theorem?
- radford-neal 5y agoThe article's actual conclusion says "we don’t know for sure whether low desmosterol from statin use increases the risk of dementia".
- JamesBarney 5y agoBut we have lots of evidence that statin use is associated with reduced risks of dementia.
- supperburg 5y agoDo we? I haven’t seen a single interventional study about that.
- JamesBarney 5y agoWe have plenty of evidence staying us is associated with reduced risks of dementia. We have far less evidence that stations reduce the risk of dementia.
- q1w2 5y agoNo, this is not the conclusion of the article. Just because there is no correlation to EXTREME brain dysfunction, that does not imply there is not measurable cognitive impairment. In fact, the article highlights the need for further research on a subset of drugs which permeate the blood-brain barrier because low levels of cholesterol synthesis are observed in the brain, and cholesterol is critical in brain function. ...and that such research may ultimately lead to recommendations to lower statin doses for some patients.
- supperburg 5y agoIs a randomized interventional study cited in the article? If not, then nothing has been proven. And that’s not accounting for the fact that statins do a hell of a lot more than just lower cholesterol.