3 ms·
That’s the thing—taste is intimately linked with effect. Every coffee drinker will notice if someone switches brands on them. That’s also why people with certa
by eurasiantiger 5y ago
That’s the thing—taste is intimately linked with effect. Every coffee drinker will notice if someone switches brands on them.
That’s also why people with certain CYP3A4 variants dislike the taste of CYP3A4-inhibiting foods such as grapefruit, and people with certain variants absolutely love them.
CYP3A4 is a liver enzyme responsible for metabolising human sex hormones, as well as most pharmaceutical and recreational drugs, including caffeine.
- eurasiantiger 5y agoHere’s a source clearly demonstrating that taste has not been selected for in our evolution, but effect on CYP3A4 has: https://link.springer.com/article/10.1186/s12862-019-1366-7 https://link.springer.com/article/10.1186/s12862-019-1366-7