Indeed, and to make it even more of a mess, regional issues also correlated with economic issues. My unorthodox opinion is that the opioid crisis started with a

Indeed, and to make it even more of a mess, regional issues also correlated with economic issues. My unorthodox opinion is that the opioid crisis started with an actual pain crisis due to the kinds of jobs that people were working, coupled with a lack of strong labor law enforcement and safety net. People were turning to pills because they were in pain.