Ah if it’s just about significance (I thought you were arguing about rate of death being negligibly different) then agreed, little difference. In this kind of s

Ah if it’s just about significance (I thought you were arguing about rate of death being negligibly different) then agreed, little difference. In this kind of scenario, errors decrease like 1/sqrt(sample size) so quadrupling the sample size leads to halving the error (which was tiny to start off with). If 1 out of 20 die of flu, the frequentist 1 sigma error is roughly 5% too, so same order of magnitude as the probability estimate. Different story with a hierarchical Bayesian model etc.