I can second this - my main driver is a Dactyl-Manuform (ortholinear), and I have zero problems on any of the other four non-ortho keyboards that I use. I also

I can second this - my main driver is a Dactyl-Manuform (ortholinear), and I have zero problems on any of the other four non-ortho keyboards that I use. I also use Dvorak as my main layout and have no problems when going back to a QWERTY one.