4 ms·
It's not that simple. For example, a protease inhibitor could have effects on biological functions that exist in viral and parasitic infections. And both Remdes
by programmarchy 5y ago
It's not that simple. For example, a protease inhibitor could have effects on biological functions that exist in viral and parasitic infections. And both Remdesivir and Ivermectin [1] have been observed to have antiviral properties in vitro.
[1] https://www.sciencedirect.com/science/article/pii/S0166354220302011 https://www.sciencedirect.com/science/article/pii/S016635422...
- veemjeem 5y agoMany things are effective against covid-19 in-vitro. When it was administered in hamsters, there was no effect on viral load. https://www.biorxiv.org/content/10.1101/2020.11.21.392639v1 https://www.biorxiv.org/content/10.1101/2020.11.21.392639v1
- programmarchy 5y agoI hadn’t seen that paper, but isn’t your statement missing the forest for the trees? If pathology was attenuated, that would help patient recovery, even if viral load wasn’t directly reduced. > Even though ivermectin had no effect on viral load, SARS-Cov-2-associated pathology was greatly attenuated. IVM had a sex-dependent and compartmentalized immunomodulatory effect, preventing clinical deterioration and reducing olfactory deficit in infected animals. Importantly, ivermectin dramatically reduced the Il-6/Il-10 ratio in lung tissue, which likely accounts for the more favorable clinical presentation in treated animals. Our data support IVM as a promising anti-COVID-19 drug candidate.
- veemjeem 5y agoYes, it seemed like it worked in hamsters, but as we well know, most drugs that work in mice don't work in humans. Besides, we already have many anti-inflammatory drugs that can reduce the cytokines, so it's a stretch to use ivermectin strictly as a steroid.