4 ms·

My understanding is that most virologists believe we will end up in an endemic situation so that is what is going to happen in the long run (the crux is how we

My understanding is that most virologists believe we will end up in an endemic situation so that is what is going to happen in the long run (the crux is how we get there). > natural immunity to more antigen sites than just the spike protean Current studies show that natural immunity does not seem to be superior to immunity from the mRNA vaccines (for immunologically naive persons) - so heuristically speaking it seems to be better to 'train' antibodies on one thing rather than several antigen sites at the same time (this may seem counter-intuitive at first but is in line with many other infectious diseases). However, once you have been vaccinated (or resp. have recovered from Covid-19) exposition to the virus (or resp. to the mRNA vaccines) will have additional benefits as you suggested!

fasteddie31003 5y ago
This study shows that natural immunity is better than the vaccines https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1 https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...
- Pyramus 5y ago
  Very interesting - thanks for posting! My knowledge was pre-Delta, and this study (in its current prepring form) suggests that for Delta, we have infection + mRNA vaccine > infection > mRNA vaccine. Upon quick screening the authors do not discuss survivorship bias - which I would have expected. Regarding what we discussed earlier the authors note: "The advantageous protection afforded by natural immunity that this analysis demonstrates could be explained by the more extensive immune response to the SARS-CoV-2 proteins than that generated by the anti-spike protein immune activation conferred by the vaccine. However, as a correlate of protection is yet to be proven, including the role of B-Cell and T-cell immunity, this remains a hypothesis."
- druidsbane 5y ago
  One thing that stands out is that the group that has been previously infected (both unvaccinated and single-jabbed post-infection) has been selected for survival already. I personally wouldn't draw the conclusion they propose from that population.

fasteddie31003 5y ago

This study shows that natural immunity is better than the vaccines https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1 https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...

Pyramus 5y ago
Very interesting - thanks for posting! My knowledge was pre-Delta, and this study (in its current prepring form) suggests that for Delta, we have infection + mRNA vaccine > infection > mRNA vaccine. Upon quick screening the authors do not discuss survivorship bias - which I would have expected. Regarding what we discussed earlier the authors note: "The advantageous protection afforded by natural immunity that this analysis demonstrates could be explained by the more extensive immune response to the SARS-CoV-2 proteins than that generated by the anti-spike protein immune activation conferred by the vaccine. However, as a correlate of protection is yet to be proven, including the role of B-Cell and T-cell immunity, this remains a hypothesis."
druidsbane 5y ago
One thing that stands out is that the group that has been previously infected (both unvaccinated and single-jabbed post-infection) has been selected for survival already. I personally wouldn't draw the conclusion they propose from that population.