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It is obvious that the antigen kinetics of ALL the vaccines require 2 shots - and they all seem to converge to ~~95% efficacy. J&J now has the data and should r
by aurizon 5y ago
It is obvious that the antigen kinetics of ALL the vaccines require 2 shots - and they all seem to converge to ~~95% efficacy.
J&J now has the data and should relaunch as a two shot going forward.
The usual vaccines with inactivated virus have the full code(broken - but antigenic) and this full code has all the little parts that a genuine infection has - inactivated but these fragments are sensed by the immune system as foreign and hold danger = antigens are created.
The rNA vaccines are spike focussed and ignore these fragmentary 'nuts and bolts' that the virus uses to construct a reproduction capable daughter virus that emerges when the cell lyses to proliferate.
I feel these nuts and bolts are the key to the higher speed spread of the delta variant - which creates 1000 times as much virus at the infection peak = each spread droplet holds 1000 times as many virions = faster spread.
I anticipate that a full examination of the reaction kinetics will reveal that the delta virus makes and uses all these nuts and bolts in a more optimal ratio, so when the cell lyses there is less waste and more fully assembled virions.
As a mechanical analog, a car factory has an assembly line fed by subassembly lines. Let us pick, engine, transmission, gas tank, headlights, and horn. All these lines need to be tuned to make the same number of their units to make complete cars. A car can not be sold with no horn, or engine etc.
If they are not in tune, the factory will only make as many cars as the slowest(critical part) line. All these excess parts will pile up, uses steel etc, waste resources and eventually fill the factory and burst the walls = lysis.
All the functional virions will go on to infect, and all the waste parts will become scavenged by the cell for re-use.
This is a crude, but representative analogy to the beta variant - I am sure there are people analysing the reaction kinetics of virion production that lead to the observed 1000 fold increase in peak virion titer as the infection peaks and then wanes. The cell does not need to hold 1000 x virions at lysis - a faster replicative cycle to lysis and repeat will lead to the 1000 fold blood titer with only 20-25% more virions at lysis due to the shorter time to lysis = more completed cycles before the immune response suppresses the virus.