I think https://mypyc.readthedocs.io/en/latest/ https://mypyc.readthedocs.io/en/latest/ is the thing you want. In my experience, it isn’t (yet) 10x performance,

I think https://mypyc.readthedocs.io/en/latest/ https://mypyc.readthedocs.io/en/latest/ is the thing you want. In my experience, it isn’t (yet) 10x performance, but it can make significant improvements.