The problem is not the MAO activity per se: although harman and norharman can cause essential tremor, depression and anxiety, as well as definitely worsen PTSD,

The problem is not the MAO activity per se: although harman and norharman can cause essential tremor, depression and anxiety, as well as definitely worsen PTSD, some of the MAO-B-inhibiting Harmala alkaloids are beneficial in e.g. Parkinson’s disease. The problem is that the Harmala alkaloids include some neurotoxic ones that cause Parkinson’s disease, and it’s practically impossible to keep them from forming in the same process.