3 ms·

…wouldn’t they just seek out a vaccine manufacturer whose vaccine has better longevity? Idk if this applies to Moderna, but even if it did, at this stage in the

…wouldn’t they just seek out a vaccine manufacturer whose vaccine has better longevity? Idk if this applies to Moderna, but even if it did, at this stage in the game there are over a dozen vaccines in production worldwide.

chitowneats 5y ago
Moderna also announced recently the effectiveness of their vaccine wanes. https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-says-covid-19-vaccine-protection-wanes-makes-case-booster-2021-09-15/ https://www.reuters.com/business/healthcare-pharmaceuticals/...
Vecr 5y ago
I don't think any of them have better durability. If you used the Biothrax reduced schedule of doses at 0 months, one month, 6 months (five months after second dose), 12 months (six months after third dose), and 18 months, you might be able to switch to boosting once a year before a predicted spike. That would be improbable even in the richest countries (look at how Anthrax went in the US military), so the probable solution would be not to care about infection, or to pray to the god of live attenuated nasal spray vaccines to save us all.
- creato 5y ago
  Figure 1 of this study (https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v1.full.pdf https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v..., linked elsewhere in the thread) shows a pretty clear difference between Moderna and Pfizer.
  - Vecr 5y ago
    It might give you a year after 3 or 4 doses instead, but I'm not sure it's worth the reactogenicity. Good point though.
bryan0 5y ago
Some studies[0] have shown Moderna does not have the same waning problems as pfizer, possibly due to pfizer’s much smaller dosage. https://amp.ft.com/content/aaddc31b-415d-43d0-b314-bc89a8b860e0 https://amp.ft.com/content/aaddc31b-415d-43d0-b314-bc89a8b86...
daenz 5y ago
Are you suggesting that the likelihood of a contract renewal worth tens of billions of taxpayer dollars rests solely on our government seeking to objectively determine the best vaccine for the taxpayers?
- Leparamour 5y ago
  Do you have a license for that sort of dangerous thinking?
andreygrehov 5y ago
Not in the near future. Pretty sure there are multi-year contracts given that the US government was able to negotiate the Pfizer vaccine price from $30+ down to $19.50 per dose.

chitowneats 5y ago

Moderna also announced recently the effectiveness of their vaccine wanes. https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-says-covid-19-vaccine-protection-wanes-makes-case-booster-2021-09-15/ https://www.reuters.com/business/healthcare-pharmaceuticals/...

Vecr 5y ago

I don't think any of them have better durability. If you used the Biothrax reduced schedule of doses at 0 months, one month, 6 months (five months after second dose), 12 months (six months after third dose), and 18 months, you might be able to switch to boosting once a year before a predicted spike. That would be improbable even in the richest countries (look at how Anthrax went in the US military), so the probable solution would be not to care about infection, or to pray to the god of live attenuated nasal spray vaccines to save us all.

creato 5y ago
Figure 1 of this study (https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v1.full.pdf https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v..., linked elsewhere in the thread) shows a pretty clear difference between Moderna and Pfizer.
- Vecr 5y ago
  It might give you a year after 3 or 4 doses instead, but I'm not sure it's worth the reactogenicity. Good point though.

bryan0 5y ago

Some studies[0] have shown Moderna does not have the same waning problems as pfizer, possibly due to pfizer’s much smaller dosage. https://amp.ft.com/content/aaddc31b-415d-43d0-b314-bc89a8b860e0 https://amp.ft.com/content/aaddc31b-415d-43d0-b314-bc89a8b86...

daenz 5y ago

Are you suggesting that the likelihood of a contract renewal worth tens of billions of taxpayer dollars rests solely on our government seeking to objectively determine the best vaccine for the taxpayers?

Leparamour 5y ago
Do you have a license for that sort of dangerous thinking?

andreygrehov 5y ago

Not in the near future. Pretty sure there are multi-year contracts given that the US government was able to negotiate the Pfizer vaccine price from $30+ down to $19.50 per dose.