We still haven’t proven that amyloid plaques don’t have at least some level of responsibility. Just because we now have the ability to clear plaques, and it has

We still haven’t proven that amyloid plaques don’t have at least some level of responsibility. Just because we now have the ability to clear plaques, and it hasn’t lead to improvement, doesn’t prove that amyloid plaques aren’t involved in disease progression. Now let me be clear, I’m not a cheerleader for any of them. I have read every original paper on the pathophysiology of AD from the 60s through to 2014 and I saw in detail the debate bounce back and forth from Amyloid to Tau with sprinkles of ‘Type 3 diabetes’ and inflammation and back again like a game of tennis. The science will come out the way it will come out. But there is nothing about our ability to remove plaques with no change in the disease that says that amyloid plaques don’t have a role in disease pathogenesis. Could be the damage is done and clearing them is irrelevant. We just don’t know enough