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> Macklin, an 18-year veteran of obesity medicine and coauthor of the Canadian Adult Obesity Clinical Practice Guidelines, is referring to his two years of expe

> Macklin, an 18-year veteran of obesity medicine and coauthor of the Canadian Adult Obesity Clinical Practice Guidelines, is referring to his two years of experience treating over a thousand people with obesity using the relatively new drug semaglutide. Sadly, another intervention pushed by Big Pharma. Selling you a future of unhealthy dependency.

Something1234 5y ago
Hey I've been on saxsenda and it is magical for how it changes my reward function. I'm usually very impulsive and it takes a long time for me to fill up. I'll get bored and snack. The drug helps the boredom snacking not even occur to me.
- JSeymourATL 5y ago
  When I first heard about OMAD, I thought these guys were hardcore nut jobs. Then I tried it—- now I’m convinced this is a smarter, healthier path. Down 70 pounds, kept off for 3 years now. Even during lockdown. > https://m.youtube.com/watch?v=V4d_YoPRKa4 https://m.youtube.com/watch?v=V4d_YoPRKa4
illegalsmile 5y ago
I don't think you're wrong but I'd also say anything to help those who are in need is a good thing. I'm healthy, I've taken the time to invest in learning and taking action to stay healthy in mind and body but a lot of people don't or can't. If a doctor said "you can lose ~60lbs by taking a weekly shot OR you can lose ~60lbs by going to a therapist, talking with a dietician and visiting with a personal trainer weekly" which are most people going to choose? One sets you up for potential dependency and yo-yo'ing the other sets you up for the rest of your life. That's assuming their insurance would even cover all of those things on a regular basis. There doesn't seem to be any money in the "ultimate weight loss therapy" and as of right now it seems like a long shot but eventually, maybe? Something has to be done about the current obesity epidemic so I'd say this is one step closer to some sort of solution.
- BizarroLand 5y ago
  One thing that is glossed over in this paper is the insulin-carb cycle, which affects obese people differently. When sugars are free in the blood stream, body fat gets preferential treatment in absorbing the extra blood sugar and converting it into more fat over everything except the brain, heart and lungs. Quick Edit: Muscles that currently have glycogen depletion seem to have precedence over fat cells This makes sense as in a normal body it's more akin to recharging the batteries so that you have energy on standby once your muscles burn through their glycogen stores. But, body fat in obese people is more like a parasite than an energy store, and since our body never destroys the fats cells it has created, even losing the weight means carrying around a hungry parasite that will feed itself any excess that you consume and will make you want to consume excess all of the time since insulin disrupts the Ghrelin hormone that indicates satiety. Its why you can put weight back on so much more quickly if you were previously fat than if you were trying to gain weight. Any form of diet and exercise alone will not resolve this issue. The only thing we have for now is to use liposuction or RF modulation to kill or remove the excess fat cells from the body, surgically excising the parasite from you.

Something1234 5y ago

Hey I've been on saxsenda and it is magical for how it changes my reward function. I'm usually very impulsive and it takes a long time for me to fill up. I'll get bored and snack. The drug helps the boredom snacking not even occur to me.

JSeymourATL 5y ago
When I first heard about OMAD, I thought these guys were hardcore nut jobs. Then I tried it—- now I’m convinced this is a smarter, healthier path. Down 70 pounds, kept off for 3 years now. Even during lockdown. > https://m.youtube.com/watch?v=V4d_YoPRKa4 https://m.youtube.com/watch?v=V4d_YoPRKa4

illegalsmile 5y ago

I don't think you're wrong but I'd also say anything to help those who are in need is a good thing. I'm healthy, I've taken the time to invest in learning and taking action to stay healthy in mind and body but a lot of people don't or can't. If a doctor said "you can lose ~60lbs by taking a weekly shot OR you can lose ~60lbs by going to a therapist, talking with a dietician and visiting with a personal trainer weekly" which are most people going to choose? One sets you up for potential dependency and yo-yo'ing the other sets you up for the rest of your life. That's assuming their insurance would even cover all of those things on a regular basis. There doesn't seem to be any money in the "ultimate weight loss therapy" and as of right now it seems like a long shot but eventually, maybe? Something has to be done about the current obesity epidemic so I'd say this is one step closer to some sort of solution.

BizarroLand 5y ago
One thing that is glossed over in this paper is the insulin-carb cycle, which affects obese people differently. When sugars are free in the blood stream, body fat gets preferential treatment in absorbing the extra blood sugar and converting it into more fat over everything except the brain, heart and lungs. Quick Edit: Muscles that currently have glycogen depletion seem to have precedence over fat cells This makes sense as in a normal body it's more akin to recharging the batteries so that you have energy on standby once your muscles burn through their glycogen stores. But, body fat in obese people is more like a parasite than an energy store, and since our body never destroys the fats cells it has created, even losing the weight means carrying around a hungry parasite that will feed itself any excess that you consume and will make you want to consume excess all of the time since insulin disrupts the Ghrelin hormone that indicates satiety. Its why you can put weight back on so much more quickly if you were previously fat than if you were trying to gain weight. Any form of diet and exercise alone will not resolve this issue. The only thing we have for now is to use liposuction or RF modulation to kill or remove the excess fat cells from the body, surgically excising the parasite from you.