Look at the receptor binding affinities in tables 1 and 3 (note that psilocin is the active metabolite of psilocybin, and that lower numbers indicate stronger b

Look at the receptor binding affinities in tables 1 and 3 (note that psilocin is the active metabolite of psilocybin, and that lower numbers indicate stronger binding) of this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110631/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110631/ LSD has about 8 times the affinity for 5-HT2A as D3, vs 25 times for psilocin. This doesn't tell us anything about how they act on the receptors, or the affinities of the endogenous ligands they're competing with, but I think it's unlikely the dopaminergic activity is significant for either drug. Edit: This does cite a paper from Nichols' lab[1] which claims LSD has a second phase of action after the serotonergic phase, where its dopaminergic activity dominates. This strikes me as plausible... I'd have to read it. [1] https://pubmed.ncbi.nlm.nih.gov/17618679/ https://pubmed.ncbi.nlm.nih.gov/17618679/