3 ms·

Edit: goddamnit, I see this is being downvoted despite being 100% correct. Yes, infections generate strong immunity. Here is a study: https://www.medrxiv.org/co

by graeme 5y ago

Edit: goddamnit, I see this is being downvoted despite being 100% correct. Yes, infections generate strong immunity. Here is a study: https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1 https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v... ————————— It is pretty useful though. Studies have found it compares well with vaccines or better. However like vaccines it also fades. And prior immunity + infection is way better than prior immunity, so being infected no reason not to get vaccinated.

nobody9999 5y ago
>It is pretty useful though. Studies have found it compares well with vaccines or better. My understanding was that there were many more studies of vaccine protection than immunity after infection. Some links to those studies of immunity after infection would be greatly appreciated.
- criticaltinker 5y ago
  A Systematic Review of the Protective Effect of Prior SARS-CoV-2 Infection on Repeat Infection https://www.medrxiv.org/content/10.1101/2021.08.27.21262741v1 https://www.medrxiv.org/content/10.1101/2021.08.27.21262741v... Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1.full.pdf https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v... Prior COVID-19 protects against reinfection, even in the absence of detectable antibodies https://www.journalofinfection.com/article/S0163-4453(21)00266-8/fulltext https://www.journalofinfection.com/article/S0163-4453(21)002... SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) https://pubmed.ncbi.nlm.nih.gov/33844963/ https://pubmed.ncbi.nlm.nih.gov/33844963/ Risk of Reinfection After Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Population-based Propensity-score Matched Cohort Study https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab495/6287116 https://academic.oup.com/cid/advance-article/doi/10.1093/cid... Assessment of the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection in an Intense Reexposure Setting https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1846/6033728 https://academic.oup.com/cid/advance-article/doi/10.1093/cid... Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2780557 https://jamanetwork.com/journals/jamainternalmedicine/fullar... SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy https://www.sciencedirect.com/science/article/pii/S2589537021001413 https://www.sciencedirect.com/science/article/pii/S258953702... Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2776810 https://jamanetwork.com/journals/jamainternalmedicine/fullar... Quantifying the risk of SARS-CoV-2 reinfection over time https://pubmed.ncbi.nlm.nih.gov/34043841/ https://pubmed.ncbi.nlm.nih.gov/34043841/ Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infection https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325385/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325385/ Persistence of neutralizing antibodies a year after SARS-CoV-2 infection https://www.medrxiv.org/content/10.1101/2021.07.13.21260426v1.full.pdf https://www.medrxiv.org/content/10.1101/2021.07.13.21260426v... Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920668/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920668/ Necessity of COVID-19 vaccination in previously infected individuals https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v3.full.pdf https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...
  - nobody9999 5y ago
    Thank you!
- gojomo 5y ago
  There are more RCTs about vaccination – because of the taboo against human challenge trials, even among the vaccinated. But there's more evidence for natural immunity, from the 1B+ people worldwide who've had COVID & recovered.

by graeme 5y ago

nobody9999 5y ago

>It is pretty useful though. Studies have found it compares well with vaccines or better. My understanding was that there were many more studies of vaccine protection than immunity after infection. Some links to those studies of immunity after infection would be greatly appreciated.

criticaltinker 5y ago
A Systematic Review of the Protective Effect of Prior SARS-CoV-2 Infection on Repeat Infection https://www.medrxiv.org/content/10.1101/2021.08.27.21262741v1 https://www.medrxiv.org/content/10.1101/2021.08.27.21262741v... Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1.full.pdf https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v... Prior COVID-19 protects against reinfection, even in the absence of detectable antibodies https://www.journalofinfection.com/article/S0163-4453(21)00266-8/fulltext https://www.journalofinfection.com/article/S0163-4453(21)002... SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) https://pubmed.ncbi.nlm.nih.gov/33844963/ https://pubmed.ncbi.nlm.nih.gov/33844963/ Risk of Reinfection After Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Population-based Propensity-score Matched Cohort Study https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab495/6287116 https://academic.oup.com/cid/advance-article/doi/10.1093/cid... Assessment of the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection in an Intense Reexposure Setting https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1846/6033728 https://academic.oup.com/cid/advance-article/doi/10.1093/cid... Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2780557 https://jamanetwork.com/journals/jamainternalmedicine/fullar... SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy https://www.sciencedirect.com/science/article/pii/S2589537021001413 https://www.sciencedirect.com/science/article/pii/S258953702... Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2776810 https://jamanetwork.com/journals/jamainternalmedicine/fullar... Quantifying the risk of SARS-CoV-2 reinfection over time https://pubmed.ncbi.nlm.nih.gov/34043841/ https://pubmed.ncbi.nlm.nih.gov/34043841/ Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infection https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325385/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325385/ Persistence of neutralizing antibodies a year after SARS-CoV-2 infection https://www.medrxiv.org/content/10.1101/2021.07.13.21260426v1.full.pdf https://www.medrxiv.org/content/10.1101/2021.07.13.21260426v... Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920668/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920668/ Necessity of COVID-19 vaccination in previously infected individuals https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v3.full.pdf https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v...
- nobody9999 5y ago
  Thank you!
gojomo 5y ago
There are more RCTs about vaccination – because of the taboo against human challenge trials, even among the vaccinated. But there's more evidence for natural immunity, from the 1B+ people worldwide who've had COVID & recovered.