4 ms·

Vaccine efficacy against infection wanes, but not severe disease and death. This is likely due to the difference in speed in which the B cells (faster) and T c

Vaccine efficacy against infection wanes, but not severe disease and death. This is likely due to the difference in speed in which the B cells (faster) and T cells (slower) wane from the vaccine. Your claim is frustrating because it is inaccurate and misleading.

belter 5y ago
As this thread seems to be confusing two concepts, maybe worthwhile to post again: "Vaccine efficacy, effectiveness and protection" https://www.who.int/news-room/feature-stories/detail/vaccine-efficacy-effectiveness-and-protection https://www.who.int/news-room/feature-stories/detail/vaccine... Vaccine efficacy is found in trials, vaccine effectiveness is dynamic depending WHEN you calculate it and its found after 'deployment in the field' "A vaccine’s efficacy is measured in a controlled clinical trial and is based on how many people who got vaccinated developed the ‘outcome of interest’ (usually disease) compared with how many people who got the placebo (dummy vaccine) developed the same outcome. Once the study is complete, the numbers of sick people in each group are compared, in order to calculate the relative risk of getting sick depending on whether or not the subjects received the vaccine. From this we get the efficacy – a measure of how much the vaccine lowered the risk of getting sick. If a vaccine has high efficacy, a lot fewer people in the group who received the vaccine got sick than the people in the group who received the placebo." vs "Vaccine effectiveness is a measure of how well vaccines work in the real world. Clinical trials include a wide range of people – a broad age range, both sexes, different ethnicities and those with known medical conditions – but they cannot be a perfect representation of the whole population. The efficacy seen in clinical trials applies to specific outcomes in a clinical trial . Effectiveness is measured by observing how well the vaccines work to protect communities as a whole. Effectiveness in the real world can differ from the efficacy measured in a trial, because we can’t predict exactly how effective vaccination will be for a much bigger and more variable population getting vaccinated in more real life conditions."

belter 5y ago

As this thread seems to be confusing two concepts, maybe worthwhile to post again: "Vaccine efficacy, effectiveness and protection" https://www.who.int/news-room/feature-stories/detail/vaccine-efficacy-effectiveness-and-protection https://www.who.int/news-room/feature-stories/detail/vaccine... Vaccine efficacy is found in trials, vaccine effectiveness is dynamic depending WHEN you calculate it and its found after 'deployment in the field' "A vaccine’s efficacy is measured in a controlled clinical trial and is based on how many people who got vaccinated developed the ‘outcome of interest’ (usually disease) compared with how many people who got the placebo (dummy vaccine) developed the same outcome. Once the study is complete, the numbers of sick people in each group are compared, in order to calculate the relative risk of getting sick depending on whether or not the subjects received the vaccine. From this we get the efficacy – a measure of how much the vaccine lowered the risk of getting sick. If a vaccine has high efficacy, a lot fewer people in the group who received the vaccine got sick than the people in the group who received the placebo." vs "Vaccine effectiveness is a measure of how well vaccines work in the real world. Clinical trials include a wide range of people – a broad age range, both sexes, different ethnicities and those with known medical conditions – but they cannot be a perfect representation of the whole population. The efficacy seen in clinical trials applies to specific outcomes in a clinical trial . Effectiveness is measured by observing how well the vaccines work to protect communities as a whole. Effectiveness in the real world can differ from the efficacy measured in a trial, because we can’t predict exactly how effective vaccination will be for a much bigger and more variable population getting vaccinated in more real life conditions."