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So they’re reducing the expression of ACE2 receptors and that gives the virus less opportunities to enter the cell. If this is true, why was it found that peopl
by IAmGraydon 5y ago
So they’re reducing the expression of ACE2 receptors and that gives the virus less opportunities to enter the cell. If this is true, why was it found that people who use ACE inhibitors (which up-regulate ACE2 receptors) don’t have an increased risk of severe Covid?
- manwe150 5y agoIn theory, that sounds like it means it wasn’t the limiting agent (for severity), but can be made a limiting factor (for infection rate). Different measures going in different directions is quite feasible for an optimization-type problem, and perhaps likely, without any actual knowledge of this domain.
- Enginerrrd 5y agoI believe hypertension was consistently found to be a big risk factor. Not sure if anyone has controlled for those on ACE inhibitors or not.