With such a small sample size, formal methods break down. The sample could be biased. In fact, it's almost guaranteed. The ability to p-hack (even inadvertently

With such a small sample size, formal methods break down. The sample could be biased. In fact, it's almost guaranteed. The ability to p-hack (even inadvertently) is extremely high. Publication bias is also practically guaranteed. These kinds of issues void significance to a reasonably high degree. At these kinds of sample sizes, the biggest issues are not going to be included or visible in the study. Unless the reported significance is extremely high, it's not meaningful.