3 ms·

Interesting, so the specific issue almost exclusively occurs with the second dose. The researchers suggest that only doing a single dose may be a happy medium.

Interesting, so the specific issue almost exclusively occurs with the second dose. The researchers suggest that only doing a single dose may be a happy medium. ”The overwhelming majority of myocarditis appears after the second dose of vaccine, so offering single shots could protect children while reducing their risk of the side effect even further.” It’d be interesting to have single dose trial data to see how that would affect % effectiveness.

linuxftw 5y ago
There's no way to show these shots are efficacious in the under 18 group with any amount of doses. Where I live, 0.05% (yes, 5 per 10k) of total deaths (remember, we're only comparing confirmed cases, actual cases much larger) affected those under 50. For those under 18, deaths since the pandemic began are literally single digits. You might decry comparing deaths of a demographic against total cases, but it's essential. People under 50 simply aren't as vulnerable to having any symptomatic level of infection. Since we're talking single digit deaths under 18, I don't think there's a scientific way to say those deaths were caused by this pandemic in any fashion. It's beyond statistically insignificant, these are most likely children on chemo or have some other very serious underlying condition.
hanche 5y ago
Hmm. Meanwhile, Norwegian data suggests that a single dose is highly protective against serious disease, yet largely ineffective (20% or so) against infection. Perhaps the best strategy is to give young people a single dose, then let the infection run its course.
- antasvara 5y ago
  The next question is what the rate of myocarditis from COVID after a single shot is. I assume myocarditis counts as serious disease, but I don't know enough to say that for certain.
chromatin 5y ago
Given that it may be related to an immune priming effect, if adopting this strategy, potential recipients must be tested for antibodies (as a result of natural infection) prior. As andecdata, I had pretty severe cytokine release / flulike syndrome after the first dose of Moderna (and I likely had a prior infection early in 2020; should have had antibody testing before getting vaccinated), whereas most describe this reaction after the second dose.

linuxftw 5y ago

There's no way to show these shots are efficacious in the under 18 group with any amount of doses. Where I live, 0.05% (yes, 5 per 10k) of total deaths (remember, we're only comparing confirmed cases, actual cases much larger) affected those under 50. For those under 18, deaths since the pandemic began are literally single digits. You might decry comparing deaths of a demographic against total cases, but it's essential. People under 50 simply aren't as vulnerable to having any symptomatic level of infection. Since we're talking single digit deaths under 18, I don't think there's a scientific way to say those deaths were caused by this pandemic in any fashion. It's beyond statistically insignificant, these are most likely children on chemo or have some other very serious underlying condition.

hanche 5y ago

Hmm. Meanwhile, Norwegian data suggests that a single dose is highly protective against serious disease, yet largely ineffective (20% or so) against infection. Perhaps the best strategy is to give young people a single dose, then let the infection run its course.

antasvara 5y ago
The next question is what the rate of myocarditis from COVID after a single shot is. I assume myocarditis counts as serious disease, but I don't know enough to say that for certain.

chromatin 5y ago

Given that it may be related to an immune priming effect, if adopting this strategy, potential recipients must be tested for antibodies (as a result of natural infection) prior. As andecdata, I had pretty severe cytokine release / flulike syndrome after the first dose of Moderna (and I likely had a prior infection early in 2020; should have had antibody testing before getting vaccinated), whereas most describe this reaction after the second dose.