I've had decent experiences with Python and Qt5. Windows was historically the painful part, but FBS¹ makes that a lot less painful nowadays. Tk also works rea

I've had decent experiences with Python and Qt5. Windows was historically the painful part, but FBS¹ makes that a lot less painful nowadays. Tk also works reasonably well if you don't need the features and native integration that Qt offers (and I'm pretty sure FBS can handle Tkinter apps just fine). The .NET ecosystem is another solid choice for cross-platform desktop app development (and nowadays even mobile, too). Avalonia² in particular looks promising, and is probably what I'd try using first should I ever be tasked with developing a desktop app again. EDIT: Also, since you mentioned it already for Linux, GTK works well enough on Windows and (IIRC) macOS, too. ---- ¹: https://build-system.fman.io/ https://build-system.fman.io/ ²: https://avaloniaui.net/ https://avaloniaui.net/