While Thunderbolt on AMD systems isn't a widespread phenomenon, there are a couple current-gen motherboards with TB3 ports, and one with TB4. (They are however,

While Thunderbolt on AMD systems isn't a widespread phenomenon, there are a couple current-gen motherboards with TB3 ports, and one with TB4. (They are however, somewhat pricey.) From what I can see, eGPU configurations are specifically called out as unsupported, and people trying have a few hurdles to jump as well.