3 ms·
I don't believe that any DNA virus would replicate via a dsRNA intermediate, since that would be an unnecessary step and therefore anti-selective. You are corr
by pak 15y ago
I don't believe that any DNA virus would replicate via a dsRNA intermediate, since that would be an unnecessary step and therefore anti-selective. You are correct that ssRNA viruses create a dsRNA template while replicating but I would think that this state is transient and therefore not a great target, unless this treatment can target dsRNA strands littered with replication forks.
- carbocation 15y agoSorry, 'stage' was misleading. As described in the PLOS ONE article on this subject, they typically undergo symmetrical transcription. So more accurately, dsRNA & ssRNA viruses typically go through a dsRNA stage. DNA viruses typically produce dsRNA during transcription.