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You're talking about the contents of the virus capsid. DRACO works by killing cells that contain viral dsRNA, which will include cells infected by most kinds o
by carbocation 15y ago
You're talking about the contents of the virus capsid.
DRACO works by killing cells that contain viral dsRNA, which will include cells infected by most kinds of DNA and RNA viruses, because those viruses usually have a dsRNA stage.
- pak 15y agoI don't believe that any DNA virus would replicate via a dsRNA intermediate, since that would be an unnecessary step and therefore anti-selective. You are correct that ssRNA viruses create a dsRNA template while replicating but I would think that this state is transient and therefore not a great target, unless this treatment can target dsRNA strands littered with replication forks.
- carbocation 15y agoSorry, 'stage' was misleading. As described in the PLOS ONE article on this subject, they typically undergo symmetrical transcription. So more accurately, dsRNA & ssRNA viruses typically go through a dsRNA stage. DNA viruses typically produce dsRNA during transcription.