6 ms·

And those who have already recovered are contributing to herd immunity at least on par with those vaccinated. Agree or disagree?

tomrod 5y ago
Results are mixed on whether prior infection is on par with vaccination. For Delta the current understanding that vaccines are 70% to 90% efficacious, and prior infection is 60% to 80% efficacious. Being both vaccinated and having prior infection shows much stronger immune response. https://catalyst.nejm.org/doi/full/10.1056/CAT.21.0288 https://catalyst.nejm.org/doi/full/10.1056/CAT.21.0288
- peteradio 5y ago
  Can you check your link? I think those are serology studies which cannot give an indication of efficacy. I believe you that recovered+vaccine gives stronger measurable antibodies but above some threshold more antibodies does not really give any indication of the two most important factors: 1) transmissibility 2) patient outcomes What do you find when we compare recovered vs vaccine for those factors?
  - tomrod 5y ago
    Reinfection rates are pretty low, partially due to immunity, partially due to behavior (if you've had it you probably know you have it again), and partially because of data drift (federated data sources don't cleanly connect despite reporting to CDC). Vaccination breakthrough rates at point of testing are something like 1/20 to 1/100 versus the canonical susceptible population, without stratifying for ages or patient outcomes or correcting for population biases.
    - peteradio 5y ago
      Thank you for the information and conversation.
      - tomrod 5y ago
        A tangent: the UK has some of the best monitoring implemented and sees antibodies in about 95% of its population. That said, reinfection rate as of June 2021 (roughly pre-Delta) was 0.4% over that population cohort. https://www.gov.uk/government/news/new-national-surveillance-of-possible-covid-19-reinfection-published-by-phe https://www.gov.uk/government/news/new-national-surveillance...

tomrod 5y ago

Results are mixed on whether prior infection is on par with vaccination. For Delta the current understanding that vaccines are 70% to 90% efficacious, and prior infection is 60% to 80% efficacious. Being both vaccinated and having prior infection shows much stronger immune response. https://catalyst.nejm.org/doi/full/10.1056/CAT.21.0288 https://catalyst.nejm.org/doi/full/10.1056/CAT.21.0288

peteradio 5y ago
Can you check your link? I think those are serology studies which cannot give an indication of efficacy. I believe you that recovered+vaccine gives stronger measurable antibodies but above some threshold more antibodies does not really give any indication of the two most important factors: 1) transmissibility 2) patient outcomes What do you find when we compare recovered vs vaccine for those factors?
- tomrod 5y ago
  Reinfection rates are pretty low, partially due to immunity, partially due to behavior (if you've had it you probably know you have it again), and partially because of data drift (federated data sources don't cleanly connect despite reporting to CDC). Vaccination breakthrough rates at point of testing are something like 1/20 to 1/100 versus the canonical susceptible population, without stratifying for ages or patient outcomes or correcting for population biases.
  - peteradio 5y ago
    Thank you for the information and conversation.
    - tomrod 5y ago
      A tangent: the UK has some of the best monitoring implemented and sees antibodies in about 95% of its population. That said, reinfection rate as of June 2021 (roughly pre-Delta) was 0.4% over that population cohort. https://www.gov.uk/government/news/new-national-surveillance-of-possible-covid-19-reinfection-published-by-phe https://www.gov.uk/government/news/new-national-surveillance...