3 ms·

Do you have a source that natural immunity is superior to vaccine-induced? Last time I checked studies showed that at least for the mRNA vaccines two shots was

Do you have a source that natural immunity is superior to vaccine-induced? Last time I checked studies showed that at least for the mRNA vaccines two shots was superior to natural immunity, as was natural immunity + mRNA booster shot. This is not surprising and in line with many other infectious diseases, see e.g. [1]. I only read the term "gold standard immunity" in a US context and it's almost always politically charged. [1] https://twitter.com/ENirenberg/status/1412865782862725125 https://twitter.com/ENirenberg/status/1412865782862725125

bgentry 5y ago
> Do you have a source that natural immunity is superior to vaccine-induced? Last time I checked studies showed that at least for the mRNA vaccines two shots was superior to natural immunity, as was natural immunity + mRNA booster shot. From this recent study out of Israel: https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1 https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v... SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naïve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naïve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected. To be clear, the study here is talking about immunity 6 months after a final dose. It appears that at least for the Pfizer vaccine, immunity against infection and even symptomatic disease decays fairly rapidly after a couple months. At that time it still appears effective at preventing severe disease and hospitalization, though we might also expect that to decay over the next few months (too early to know). Natural immunity decays too, but not nearly as rapidly per this study.

bgentry 5y ago

> Do you have a source that natural immunity is superior to vaccine-induced? Last time I checked studies showed that at least for the mRNA vaccines two shots was superior to natural immunity, as was natural immunity + mRNA booster shot. From this recent study out of Israel: https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1 https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v... SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naïve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naïve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected. To be clear, the study here is talking about immunity 6 months after a final dose. It appears that at least for the Pfizer vaccine, immunity against infection and even symptomatic disease decays fairly rapidly after a couple months. At that time it still appears effective at preventing severe disease and hospitalization, though we might also expect that to decay over the next few months (too early to know). Natural immunity decays too, but not nearly as rapidly per this study.