6 ms·
The effect of caffeine is controlled by several genes. One is the CYP1A2 gene that encodes for a liver enzyme critical for the metabolism of caffeine. Another i
by gwynplaine 5y ago
The effect of caffeine is controlled by several genes.
One is the CYP1A2 gene that encodes for a liver enzyme critical for the metabolism of caffeine. Another is the AHR gene, which controls when and how the CYP1A2 gene is switched on and off. The general population have variants of these genes and so experience different response to similar doses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777290/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777290/