4 ms·
I always wonder if some of the self reported dosage variability for pills comes from differences in absorbtion of pills. Maybe some ppl's stomach acids or bacte
by polskibus 5y ago
I always wonder if some of the self reported dosage variability for pills comes from differences in absorbtion of pills. Maybe some ppl's stomach acids or bacterial flora destroy particular molecules more or prevents absorption more than in other ppl?
- xvedejas 5y agoSublingual tablets are available which result in a much more reliably fast absorption. I recommend them for anyone who wants less variability from their melatonin use.
- polskibus 5y agoAny links on why are sublingual better wrt absorption?
- relaxing 5y agoShort answer is because the chemical goes directly through the membrane into the bloodstream. https://en.m.wikipedia.org/wiki/Sublingual_administration https://en.m.wikipedia.org/wiki/Sublingual_administration
- nextaccountic 5y agoIt bypasses the stomach and intestines. It also bypasses liver metabolism (first-pass metabolism) https://en.wikipedia.org/wiki/Sublingual_administration#Principle https://en.wikipedia.org/wiki/Sublingual_administration#Prin... https://en.wikipedia.org/wiki/First_pass_effect https://en.wikipedia.org/wiki/First_pass_effect
- glanard_frugner 5y agoyou can see this with pot edibles, if you take one on an empty stomach it takes forever to kick in and sometimes doesn’t work very well, but if you eat the same one after a large fatty meal it will kick in fast and strong