Most "sites" work entirely fine with uBlock. Sometimes there will be an issue with form filling and web-apps with built in tracking (via mixpanel or something)

Most "sites" work entirely fine with uBlock. Sometimes there will be an issue with form filling and web-apps with built in tracking (via mixpanel or something) will break, but it's a seconds worth of effort to disable it on a particular site. If you run into repeated problems you can set permanent rules allowing certain domains. Overall it's a very minor hassle in the scheme of things.