I've never had to use it myself, but what part of the JNI/JNA is problematic? One thing I'd sorta fantasized about is (in a very hand wavey way) using Clojure

I've never had to use it myself, but what part of the JNI/JNA is problematic? One thing I'd sorta fantasized about is (in a very hand wavey way) using Clojure + ClojureCL to run OpenCL kernels. In theory if you were to bundled your JAR with POCL.. you could selectively run your tight-loops/kernels on the CPU or GPU. So it'd be effectively like launching little C snippets. Furthermore, from what I remember, kernels are compiled and executed at run time - so it'd really fit with the whole REPL workflow and they would effectively simply be inline strings of C code that get executed I think the main catch for the moment is that ClojureCL uses a MKL matrices to talk to the OpenCL driver (driver? dispatcher? I might be mixing up my terms) - but that could be modified to a JVM container Probably my own bias - but the only time I've really been let down by Clojure and missed native was when I need to optimize a tight loop. Once you optimized Clojure past a certain point (to eliminate reflection, boxing issues, destructuring etc.) it starts to get ugly.