3 ms·

Please investigate GABA-B _agonists_ Look for studies around Binge Eating Disorders, Withdrawal from substance abuse. Good studies available in lab rat settin

by sdze 5y ago

Please investigate GABA-B _agonists_ Look for studies around Binge Eating Disorders, Withdrawal from substance abuse. Good studies available in lab rat settings. Unfortunately mostly small human studies (Especially about Baclofen). But I gave it a shot.

bserge 5y ago
Baclofen and Phenibut, and other agonists, are worse than Gabapentin in my experience, likely because I have lower than normal levels of GABA. It's the only thing that explains how it helps me a lot with depression and anxiety, I get none of the negative effects and have very few withdrawal effects. But I haven't noticed much of an effect on eating tbh. Did help me drink much less alcohol though. I'm likely drinking because alcohol indirectly affects GABA receptors.
- fnord77 5y ago
  I found gabapentin was mild. Phenibut was like a sledgehammer and has a nasty rep for habit formation. pregablin made me stupid. literally interfered with my cognition
  - bserge 5y ago
    How were you taking it? It can be mild if taken throughout the day (600mg morning and 300-600mg evening before food was perfect for me). It can also be used in "burst mode" (great for a create or a work session) either by taking 1200mg+ at once or best 300mg every 20min, eat something after 900mg, never exceed 1.2-1.8g. It can be recreational as it often (but not always) has the good effects of alcohol (and a similar hangover). But it takes ~2hrs to feel the effects and it lasts 2-3hrs. If you try to take more you get nasty effects like nausea, tiredness, stupidity and sleepiness. Some people report these effects in general even after a small dosage, so it looks like not everyone reacts well to it. Haven't tried pregabalin, wish I could.
raducu 5y ago
Won't all gaba agonists downregulate those gaba receptors? Afik GABA system is something you really shouldn't mess with? I thought you'd suggest some novel substance to upregulate GABA without tollerance.

by sdze 5y ago

bserge 5y ago

Baclofen and Phenibut, and other agonists, are worse than Gabapentin in my experience, likely because I have lower than normal levels of GABA. It's the only thing that explains how it helps me a lot with depression and anxiety, I get none of the negative effects and have very few withdrawal effects. But I haven't noticed much of an effect on eating tbh. Did help me drink much less alcohol though. I'm likely drinking because alcohol indirectly affects GABA receptors.

fnord77 5y ago
I found gabapentin was mild. Phenibut was like a sledgehammer and has a nasty rep for habit formation. pregablin made me stupid. literally interfered with my cognition
- bserge 5y ago
  How were you taking it? It can be mild if taken throughout the day (600mg morning and 300-600mg evening before food was perfect for me). It can also be used in "burst mode" (great for a create or a work session) either by taking 1200mg+ at once or best 300mg every 20min, eat something after 900mg, never exceed 1.2-1.8g. It can be recreational as it often (but not always) has the good effects of alcohol (and a similar hangover). But it takes ~2hrs to feel the effects and it lasts 2-3hrs. If you try to take more you get nasty effects like nausea, tiredness, stupidity and sleepiness. Some people report these effects in general even after a small dosage, so it looks like not everyone reacts well to it. Haven't tried pregabalin, wish I could.

raducu 5y ago

Won't all gaba agonists downregulate those gaba receptors? Afik GABA system is something you really shouldn't mess with? I thought you'd suggest some novel substance to upregulate GABA without tollerance.