Vaccination has been shown to induce an immune response including T cells [1]. However, vaccination induces a slightly different immune response compared to na

Vaccination has been shown to induce an immune response including T cells [1]. However, vaccination induces a slightly different immune response compared to natural infection [2][3] . These differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. [1] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 [2] Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection https://pubmed.ncbi.nlm.nih.gov/34103407/ https://pubmed.ncbi.nlm.nih.gov/34103407/ [3] mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition https://www.medrxiv.org/content/medrxiv/early/2021/04/07/2021.04.05.21254952.full.pdf https://www.medrxiv.org/content/medrxiv/early/2021/04/07/202...