4 ms·

You think you’re fighting misinformation, but GP could be right in terms of T cell response.

• criticaltinker 5y ago
  Vaccination has been shown to induce an immune response including T cells [1]. However, vaccination induces a slightly different immune response compared to natural infection [2][3] . These differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. [1] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3 [2] Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection https://pubmed.ncbi.nlm.nih.gov/34103407/ https://pubmed.ncbi.nlm.nih.gov/34103407/ [3] mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition https://www.medrxiv.org/content/medrxiv/early/2021/04/07/2021.04.05.21254952.full.pdf https://www.medrxiv.org/content/medrxiv/early/2021/04/07/202...
  • jonny_eh 5y ago
    > differences may account for variation in effectiveness between vaccine-induced and naturally acquired immunity. What's the variation you are referring to?
    • inter_netuser 5y ago
      antibodies produced in a primary infection target a lot more than spike protein, in some pre-prints. It's all preliminary data. However, the sinopharm vaccine, which is the whole virus, not just spike protein, seems to lose effectiveness after several months as well.
• aeternum 5y ago
  Then GP should have posted some evidence. It's lazy and hinders discourse to post a conjecture that can be quickly disproved with a quick search.